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KMID : 0923620140140040182
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Immune Network
2014 Volume.14 No. 4 p.182 ~ p.186
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Interplay between Inflammatory Responses and Lymphatic Vessels
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Shin Ki-Hyuk
Lee Seung-Hyo
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Abstract
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Lymphatic vessels are routes for leukocyte migration and flu-id drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lym-phatic endothelial cell proliferation and chemokine pro-duction, thereby resulting in lymphangiogenesis. Further-more, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.
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KEYWORD
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Lymphangiogenesis, Lymphatic vessels, Inflam-mation, Immune responses
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